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Evaluation of hepatocellular carcinoma models for preclinical studies

Drug Discovery Today: Disease Models, ISSN: 1740-6757, Vol: 2, Issue: 1, Page: 41-49
2005
  • 9
    Citations
  • 0
    Usage
  • 27
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    9
    • Citation Indexes
      9
  • Captures
    27

Review Description

Research on hepatocellular carcinoma (HCC) therapy requires appropriate models. Unfortunately, the choice of model often reflects experimental convenience rather than direct relevance to the molecular phenotype and development of the disease. This constitutes a significant obstacle for evaluating the responses to experimental treatments. Therefore, studies that compare the molecular characteristics of human and animal HCC are of enormous importance. Here, we review current models of HCC, highlighting the best candidates for future preclinical investigations.

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