PlumX Metrics
Embed PlumX Metrics

Disorders of complement regulation

Drug Discovery Today: Disease Models, ISSN: 1740-6757, Vol: 11, Page: 29-35
2014
  • 0
    Citations
  • 0
    Usage
  • 4
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Review Description

Experiments in genetically engineered mice have elucidated the key role of the complement system in the pathogenesis of several renal disorders. This has led to the clinical evaluation of agents that inhibit complement activation in patients with complement-mediated kidney disease. Here we discuss the mouse models of lupus nephritis, C3 glomerulopathy and atypical hemolytic uremic syndrome, together with an inducible model of antiphospholipid syndrome. Evidence for and against therapeutic modulation of specific complement pathways in these disorders is presented.

Bibliographic Details

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know