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RNA splicing to cytoskeleton: A new path to cardiomyocyte ploidy and division?

Developmental Cell, ISSN: 1534-5807, Vol: 57, Issue: 8, Page: 945-946
2022
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Article Description

Mammalian cardiomyocytes (CMs) undergo polyploidization after birth, accompanied by the loss of CM proliferation and regenerative capacity, although why this occurs is still poorly understood. In this issue of Developmental Cell, Gan et al. show that premature CM polyploidization, through defective RNA splicing, is detrimental to ventricular wall growth.

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