Impact of sphingolipid synthesis inhibition on the drug susceptibility patterns of Trichophyton species
Diagnostic Microbiology and Infectious Disease, ISSN: 0732-8893, Vol: 109, Issue: 2, Page: 116283
2024
- 1Citations
- 2Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
The well known dermatophyte infections caused by Trichophyton species are an ambiguous problem to treat using the present arsenal of antifungals. This study expounds on the effect of inhibition of sphingolipid pathway on Trichophyton growth. Findings from the drug susceptibility assays suggest sphingolipid inhibition severely restricts the growth of T. interdigitale and T. tonsurans. The observed synergistic effects of combinations of sphingolipid inhibitor and conventional drugs provide a promising treatment strategy against Trichophyton infection.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0732889324001123; http://dx.doi.org/10.1016/j.diagmicrobio.2024.116283; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85189495065&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/38574446; https://linkinghub.elsevier.com/retrieve/pii/S0732889324001123; https://dx.doi.org/10.1016/j.diagmicrobio.2024.116283
Elsevier BV
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