Data of transcriptional effects of the merbarone-mediated inhibition of TOP2
Data in Brief, ISSN: 2352-3409, Vol: 44, Page: 108499
2022
- 3Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Captures3
- Readers3
Dataset Description
Type II DNA topoisomerases relax topological stress by transiently gating DNA passage in a controlled cut-and-reseal mechanism that affects both DNA strands. Therefore, they are essential to overcome topological problems associated with DNA metabolism. Their aberrant activity results in the generation of DNA double-strand breaks, which can seriously compromise cell survival and genome integrity. Here, we profile the transcriptome of human-telomerase-immortalized retinal pigment epithelial 1 (RPE-1) cells when treated with merbarone, a drug that catalytically inhibits type II DNA topoisomerases. We performed RNA-Seq after 4 and 8 h of merbarone treatment and compared transcriptional profiles versus untreated samples. We report raw sequencing data together with lists of gene counts and differentially expressed genes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S235234092200693X; http://dx.doi.org/10.1016/j.dib.2022.108499; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85135896711&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/35983130; https://linkinghub.elsevier.com/retrieve/pii/S235234092200693X; https://dx.doi.org/10.1016/j.dib.2022.108499
Elsevier BV
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