Nutritional secondary hyperparathyroidism in rabbits
Domestic Animal Endocrinology, ISSN: 0739-7240, Vol: 28, Issue: 4, Page: 380-390
2005
- 17Citations
- 28Captures
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Metrics Details
- Citations17
- Citation Indexes17
- 17
- CrossRef13
- Captures28
- Readers28
- 28
Article Description
The present study was designed to document the effect of a low (0.6%) calcium-high (1.2%) phosphorus (LCaHP) diet on the development of parathyroid gland hyperplasia in rabbits and to describe the dynamics of parathyroid function (PTH–Ca 2+ curves) in rabbits with nutritional secondary hyperparathyroidism (N2HPT). Parathyroid gland weight, parathyroid cell proliferation (measured as percentage of cells in S-phase), and parathyroid calcium (CaRmRNA) and Vitamin D (VDRmRNA) receptor expression were measured in normal rabbits and in rabbits with N2HPT. The PTH–Ca 2+ curve was studied in normal rabbits (Group I) and in rabbits with N2HPT at two stages: 2–3 weeks (Group IIA) and 5–6 weeks (Group IIB) after being fed LCaHP diet. An increase in parathyroid gland weight and percentage of cells in S-phase was detected in the course of N2HPT. After receiving a LCaHP diet for 6 weeks rabbits had decreased levels of CaRmRNA but VDRmRNA remained unchanged. A progressive increase in the concentrations of plasma PTH (Group IIA = 167 ± 14 pg/ml and Group IIB = 377 ± 54 pg/ml, P < 0.05 versus Group I = 27 ± 3 pg/ml) was detected in the rabbits fed a LCaHP diet. This was accompanied by an increase in maximal and minimal PTH, reductions in plasma Ca 2+ and calcitriol and elevations in plasma phosphate and creatinine. In conclusion, feeding a LCaHPD results in a rapid induction of N2HPT in rabbits. After 6 weeks on the LCaHPD rabbits develop parathyroid hyperplasia characterized by increases in PTH secretion, glandular weight and proliferation and by a decrease in CaRmRNA.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0739724005000032; http://dx.doi.org/10.1016/j.domaniend.2005.01.002; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=16844381573&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/15826773; https://linkinghub.elsevier.com/retrieve/pii/S0739724005000032; https://dx.doi.org/10.1016/j.domaniend.2005.01.002
Elsevier BV
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