Understanding missing proteins: a functional perspective
Drug Discovery Today, ISSN: 1359-6446, Vol: 23, Issue: 3, Page: 644-651
2018
- 13Citations
- 27Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations13
- Citation Indexes13
- 13
- CrossRef8
- Captures27
- Readers27
- 27
- Mentions1
- News Mentions1
- 1
Most Recent News
Understanding Missing Proteins: Why Should You Care?
We all know that proteins are important. Proteins are large macromolecules which play important roles in our bodies, working as enzymes, maintaining the structural... The post Understanding Missing Proteins: Why Should You Care? appeared first on Science Trends.
Review Description
A missing protein (MP) is an unconfirmed genetic sequence for which a protein product is not yet detected. Currently, MPs are tiered based on supporting evidence mainly in the form of protein existence (PE) classification. As we discuss here, this definition is overly restrictive because proteins go missing in day-to-day proteomics as a result of low abundance, lack of sequence specificity, splice variants, and so on. Thus, we propose a broader functional classification of MPs that complements PE classification, discuss major causes, and examine three corresponding solution tiers: biological, technical, and informatics. We assert that informatics-driven solutions would have a major role in resolving the MP problem (MPP).
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1359644617302829; http://dx.doi.org/10.1016/j.drudis.2017.11.011; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85034998786&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/29158195; https://linkinghub.elsevier.com/retrieve/pii/S1359644617302829; https://dx.doi.org/10.1016/j.drudis.2017.11.011
Elsevier BV
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