PlumX Metrics
Embed PlumX Metrics

Vascular thiol isomerases: Structures, regulatory mechanisms, and inhibitor development

Drug Discovery Today, ISSN: 1359-6446, Vol: 27, Issue: 2, Page: 626-635
2022
  • 8
    Citations
  • 0
    Usage
  • 9
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Review Description

Vascular thiol isomerases (VTIs), including PDI, ERp5, ERp57, ERp72, and thioredoxin-related transmembrane protein 1 (TMX1), have important roles in platelet aggregation and thrombosis. Research on VTIs, their substrates in thrombosis, their regulatory mechanisms, and inhibitor development is an emerging and rapidly evolving area in vascular biology. Here, we describe the structures and functions of VTIs, summarize the relationship between the vascular TIs and thrombosis, and focus on the development of VTI inhibitors for antithrombotic applications.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know