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Stimuli-sensitive drug delivery systems for site-specific antibiotic release

Drug Discovery Today, ISSN: 1359-6446, Vol: 27, Issue: 6, Page: 1698-1705
2022
  • 35
    Citations
  • 0
    Usage
  • 36
    Captures
  • 0
    Mentions
  • 53
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    35
  • Captures
    36
  • Social Media
    53
    • Shares, Likes & Comments
      53
      • Facebook
        53

Review Description

Site-specific delivery of antibiotics has always been a high-priority area in pharmaceutical research. Conventionally used antibiotics suffer several limitations, such as low accumulation and penetration in diseased cells/tissues, limited bioavailability of drugs, drug resistance, and off-target toxicity. To overcome these limitations, several strategies have been exploited for delivering antibiotics to the site of infection, such as the use of stimuli-responsive antibiotic delivery systems, which can release antibiotics in a controlled and timely fashion. These stimuli can either be exogenous (light, magnetism, ultrasound, and electrical) or endogenous (pH, redox reactions, and enzymatic). In this review, we present a summary of recent developments in the field of stimuli-based targeted drug delivery systems for the site-specific release of antibiotics.

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