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Expression of nuclear FIH independently predicts overall survival of clear cell renal cell carcinoma patients

European Journal of Cancer, ISSN: 0959-8049, Vol: 46, Issue: 18, Page: 3375-3382
2010
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Article Description

The hypoxia inducible factor (HIF) pathway plays an important role in sporadic clear cell renal cell carcinoma (ccRCC) by stimulating processes of angiogenesis, cell proliferation, cell survival and metastases formation. Herein, we evaluate the significance of upstream proteins directly regulating the HIF pathway; the prolyl hydroxylases domain proteins (PHD)1, 2 and 3 and factor-inhibiting HIF (FIH), as prognostic markers for ccRCC.

Bibliographic Details

Kroeze, Stephanie G C; Vermaat, Joost S; van Brussel, Aram; van Melick, Harm H E; Voest, Emile E; Jonges, Trudy G N; van Diest, Paul J; Hinrichs, John; Bosch, J L H Ruud; Jans, Judith J M

Elsevier BV

Medicine; Biochemistry, Genetics and Molecular Biology

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