Cell state plasticity in neuroblastoma
EJC Paediatric Oncology, ISSN: 2772-610X, Vol: 4, Page: 100184
2024
- 10Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Captures10
- Readers10
- 10
- Mentions1
- News Mentions1
- 1
Most Recent News
Reports from St. Jude Children's Research Hospital Advance Knowledge in Neuroblastomas (Cell state plasticity in neuroblastoma)
2024 DEC 09 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Daily -- Investigators discuss new findings in neuroblastomas. According to
Article Description
Evolving evidence indicates that tumor cells can transdifferentiate between distinct transcriptionally-determined cell states with changes in resultant phenotypes, a phenomenon known as cellular plasticity. These transitions are not driven by genetic mutations and typically in contrast to normal developmental processes, may proceed bidirectionally. Here, we review the role of cellular plasticity in the aggressive childhood solid tumor, neuroblastoma. We discuss the detection of two cell states, termed mesenchymal (MES) and adrenergic (ADRN), their properties and the transcriptional circuitries that control them, their relation to the normal embryogenesis of the sympathetic nervous system and their potential role in drug resistance, escape from therapy and development of relapse.
Bibliographic Details
Elsevier BV
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