Synthesis and biological evaluation of a new family of anti -benzylanilinosulfonamides as CA IX inhibitors
European Journal of Medicinal Chemistry, ISSN: 0223-5234, Vol: 44, Issue: 2, Page: 511-518
2009
- 13Citations
- 19Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations13
- Citation Indexes13
- 13
- CrossRef10
- Captures19
- Readers19
- 19
Article Description
We report the synthesis and the pharmacological evaluation of a new class of human carbonic anhydrase (hCA) inhibitors prepared regio- and stereoselectively by reacting sulfanilamide with ethyl trans -phenylglycidate in the presence of cobalt(II) chloride. Various derivatizations of the ester moiety in the parent compound led to a small library of derivatives (2 R,3 R and 2 S,3 S ) which displayed interesting inhibitory activities towards the human tumor-associated isoform CA IX. One of the new compounds shows high selectivity in inhibiting hCA IX compared to the two physiologically relevant, cytosolic isozymes hCA I and hCA II. A molecular modeling study was conducted in order to simulate the binding mode of this new family of enzyme inhibitors within the active sites of hCA IX and hCA II.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0223523408001839; http://dx.doi.org/10.1016/j.ejmech.2008.03.034; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=60149101971&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/18479784; https://linkinghub.elsevier.com/retrieve/pii/S0223523408001839; https://dx.doi.org/10.1016/j.ejmech.2008.03.034
Elsevier BV
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