Fibrate-derived N -(methylsulfonyl)amides with antagonistic properties on PPARα
European Journal of Medicinal Chemistry, ISSN: 0223-5234, Vol: 58, Page: 317-322
2012
- 23Citations
- 13Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations23
- Citation Indexes23
- 23
- CrossRef20
- Captures13
- Readers13
- 13
Article Description
The identification of novel PPAR ligands represents an attractive research to fully understand the complex biological pathways regulated by these receptors. Selective PPAR modulators, inverse agonists and antagonists of three PPAR isoforms could help to clarify biological effects on lipid and glucose homeostasis. Here we describe the identification of a group of N -(methylsulfonyl)amides, derived from PPARα agonist carboxylic acids. Transactivation and FRET assay confirmed an antagonist behaviour on PPARα for some of these compounds, with submicromolar IC 50. A preliminary analysis on selectivity α/γ revealed different profiles of inhibition or activation.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0223523412006228; http://dx.doi.org/10.1016/j.ejmech.2012.10.019; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84868232848&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/23137448; https://linkinghub.elsevier.com/retrieve/pii/S0223523412006228; https://dx.doi.org/10.1016/j.ejmech.2012.10.019
Elsevier BV
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