Structure–activity relationships studies of quinoxalinone derivatives as aldose reductase inhibitors
European Journal of Medicinal Chemistry, ISSN: 0223-5234, Vol: 80, Page: 383-392
2014
- 127Citations
- 20Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations127
- Citation Indexes127
- 127
- CrossRef71
- Captures20
- Readers20
- 20
Article Description
Novel quinoxalinone derivatives were synthesized and tested for their inhibitory activity against aldose reductase. Among them, N1-acetate derivatives had significant activity in a range of IC 50 values from low micromolar to submicromolar, and compound 15a bearing a C3-phenethyl side chain was identified as the most potent inhibitor with an IC 50 value of 0.143 μM. The structure–activity studies suggested that both C3-phenethyl and C6-NO 2 groups play an important role in enhancing the activity and selectivity of the quinoxalinone based inhibitors.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0223523414003687; http://dx.doi.org/10.1016/j.ejmech.2014.04.047; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84899822325&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/24793885; https://linkinghub.elsevier.com/retrieve/pii/S0223523414003687; https://dx.doi.org/10.1016/j.ejmech.2014.04.047
Elsevier BV
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