Lysophosphatidic acid (LPA) receptor modulators: Structural features and recent development
European Journal of Medicinal Chemistry, ISSN: 0223-5234, Vol: 222, Page: 113574
2021
- 33Citations
- 21Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Review Description
Lysophosphatidic acid (LPA) activates six LPA receptors (LPAR 1-6 ) and regulates various cellular activities such as cell proliferation, cytoprotection, and wound healing. Many studies elucidated the pathological outcomes of LPA are due to the alteration in signaling pathways, which include migration and invasion of cancer cells, fibrosis, atherosclerosis, and inflammation. Current pathophysiological research on LPA and its receptors provides a means that LPA receptors are new therapeutic targets for disorders associated with LPA. Various chemical modulators are developed and are under investigation to treat a wide range of pathological complications. This review summarizes the physiological and pathological roles of LPA signaling, development of various LPA modulators, their structural features, patents, and their clinical outcomes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0223523421004232; http://dx.doi.org/10.1016/j.ejmech.2021.113574; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85108114964&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/34126459; https://linkinghub.elsevier.com/retrieve/pii/S0223523421004232; https://dx.doi.org/10.1016/j.ejmech.2021.113574
Elsevier BV
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