Gastro-intestinal delivery of influenza subunit vaccine formulation adjuvanted with Gram-positive enhancer matrix (GEM) particles
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 0939-6411, Vol: 76, Issue: 3, Page: 470-474
2010
- 26Citations
- 35Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations26
- Citation Indexes25
- 25
- CrossRef17
- Patent Family Citations1
- 1
- Captures35
- Readers35
- 35
Article Description
In this study, a liquid formulation of influenza subunit vaccine admixed with Gram-positive enhancer matrix (GEM) particles as adjuvant was delivered to upper and lower parts of intestinal tract. The aim was to determine the most effective immunization site in the intestines. Mice were vaccinated with a liquid formulation of GEM and influenza subunit vaccine orally and rectally. The oral administration of the vaccine with GEM particles induced a better systemic and mucosal immune response than oral (vaccine only) and rectal (with and without adjuvant) immunizations. Rectal administration elicited high IgG1 responses but little IgG2a, indicating a Th2 dominated immune response. In contrast, the oral immunization with GEM particles elicited a balanced IgG1 and IgG2a response. In conclusion, our results demonstrate that GEM-adjuvanted influenza vaccine should be targeted to the upper part of the intestinal tract.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0939641110002134; http://dx.doi.org/10.1016/j.ejpb.2010.08.003; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78549254130&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/20719246; https://linkinghub.elsevier.com/retrieve/pii/S0939641110002134; https://dx.doi.org/10.1016/j.ejpb.2010.08.003
Elsevier BV
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