Pharmacological treatment strategies: Mechanisms of antiepileptic drugs
Epileptology, ISSN: 2212-8220, Vol: 1, Issue: 1, Page: 31-37
2013
- 14Citations
- 47Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
Both, the development of novel antiepileptic drugs as well as ongoing research regarding the mechanism of action of established antiepileptic drugs, are continuously increasing the level of complexity in the spectrum of molecular targets relevant for epilepsy therapy. Although we are far from a reliable prediction of the optimal choice for polytherapy in individual patients, evidence exists that the mechanisms of action of the combination partners can matter regarding tolerability and efficacy. Moreover, the current state of knowledge as well as the limitations in our understanding should guide future research aiming for a more detailed elucidation of the exact mechanisms of target modulation as well as a more comprehensive investigation of the impact of genetics and pathophysiological mechanisms on interindividual differences in expression and function of antiepileptic drug targets. Therefore, this review gives a short overview of the mechanism of action of currently marketed antiepileptic drugs.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2212822012000087; http://dx.doi.org/10.1016/j.epilep.2012.11.004; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84878369311&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S2212822012000087; https://dx.doi.org/10.1016/j.epilep.2012.11.004
Elsevier BV
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