Differential response of lens crystallins and corneal crystallins in degenerative corneas
Experimental Eye Research, ISSN: 0014-4835, Vol: 96, Issue: 1, Page: 55-64
2012
- 2Citations
- 10Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations2
- Citation Indexes2
- CrossRef1
- Captures10
- Readers10
- 10
Article Description
Corneal degenerations, occurring either spontaneously or as a complication to other diseases, cause vision problems by endangering corneal transparency. Our past cornea research projects involving mice revealed that some recruited mice presented corneal problems similar to human corneal degeneration. The present study examines the histology of diseased mice corneas, including ultrastructure. Genome-wide microarray and proteomic methods were utilized to screen for molecular changes in the diseased corneas. It was found that abnormalities affected mainly anterior layers of the corneas. The most often observed histological abnormalities included neoplasm or detachment of the epithelial layer, erosion or breakage of Bowman membranes, blood vessel formation, and bleeding in the stroma. Microarray assay showed that among the 46 up-regulated probes in diseased corneas, 13 were for lens crystallins. However, all corneal crystallins genes remained unchanged. αA-crystallin was among the proteins that showed the greatest increase in diseased corneas, as detected by gel electrophoresis. We propose that lens crystallins, rather than corneal crystallins, are involved in the pathological process of corneal degeneration. Further study along these lines would provide insight into the mechanism of corneal transparency.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0014483511004210; http://dx.doi.org/10.1016/j.exer.2011.12.024; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84862786846&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/22233703; https://linkinghub.elsevier.com/retrieve/pii/S0014483511004210; https://dx.doi.org/10.1016/j.exer.2011.12.024
Elsevier BV
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