Collagen XII regulates stromal wound closure
Experimental Eye Research, ISSN: 0014-4835, Vol: 230, Page: 109456
2023
- 5Citations
- 7Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations5
- Citation Indexes5
- CrossRef1
- Captures7
- Readers7
Article Description
The role of collagen XII in regulating injury repair and reestablishment of corneal function is unknown. This manuscript aims to investigate the role(s) of collagen XII in the repair of incisional and debridement injuries in an adult mouse model. Two different types of injury in wild type and Col12a1 −/− corneas were created to investigate the effects of collagen XII -in wound repair and scar formation-by using clinical photographs, immunohistology, second harmonic generation imaging and electron microscopy. Results showed that collagen XII is a regulator of wound closure after incisional injuries. Absence of collagen XII retarded wound closure and the wound healing process. These findings show that collagen XII regulates fibrillogenesis, CD68 cell lineage infiltration, and myofibroblast survival following injury. In vitro studies suggest that collagen XII regulates deposition of an early and provisional matrix by interacting with two proteins regulating early matrix deposition: fibronectin and LTBP1(latent transforming growth factor β binding protein 1). In conclusion, collagen XII regulates tissue repair in corneal incisional wounds. Understanding the function of collagen XII during wound healing has significant translational value.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0014483523000775; http://dx.doi.org/10.1016/j.exer.2023.109456; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85151427063&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/36967080; https://linkinghub.elsevier.com/retrieve/pii/S0014483523000775; https://dx.doi.org/10.1016/j.exer.2023.109456
Elsevier BV
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