Whey protein peptide PEW attenuates hyperuricemia and associated renal inflammation in potassium oxonate and hypoxanthine-induced rat
Food Bioscience, ISSN: 2212-4292, Vol: 51, Page: 102311
2023
- 11Citations
- 5Captures
- 1Mentions
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Most Recent News
Findings from Harbin Institute of Technology Provides New Data on Life Science (Whey Protein Peptide Pew Attenuates Hyperuricemia and Associated Renal Inflammation In Potassium Oxonate and Hypoxanthine-induced Rat)
2023 FEB 13 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- Current study results on Life Science have been
Article Description
Pro-Glu-Trp (PEW), a whey protein-derived peptide, has been previously shown in vitro to have anti-hyperuricemic potential. The current study further evaluated the roles and the underlying mechanism of PEW in the management of hyperuricemia (HUA) in rat induced by potassium oxonate (PO) and hypoxanthine. Results revealed that PEW significantly reduced the levels of uric acid (UA), creatinine (Cr), and blood urea nitrogen (BUN) in serum, and effectively suppressed the activities of xanthine oxidase (XOD) associated with UA synthesis and modulated the expression of organic ion transporters related to UA excretion. Moreover, PEW alleviated UA-induced renal inflammation by regulating oxidative stress, suppressing the level of pro-inflammatory cytokines, and inhibiting the activation of NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome and Toll-like receptor 4/myeloid differentiation factor 88/NF-kappaB (TLR4/MyD88/NF-κB) signaling pathway. Taken together, these relults indicated that PEW improved HUA and renal inflammation by inhibiting UA synthesis, promoting renal UA excretion and suppressing NLRP3 inflammasome and TLR4/MyD88/NF-κB signaling pathways.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2212429222007702; http://dx.doi.org/10.1016/j.fbio.2022.102311; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85144403718&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S2212429222007702; https://dx.doi.org/10.1016/j.fbio.2022.102311
Elsevier BV
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