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A novel toxic alkaloid from poison hemlock ( Conium maculatum L., Apiaceae): Identification, synthesis and antinociceptive activity

Food and Chemical Toxicology, ISSN: 0278-6915, Vol: 50, Issue: 2, Page: 274-279
2012
  • 36
    Citations
  • 0
    Usage
  • 57
    Captures
  • 0
    Mentions
  • 1
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    36
    • Citation Indexes
      34
    • Patent Family Citations
      1
      • Patent Families
        1
    • Policy Citations
      1
      • Policy Citation
        1
  • Captures
    57
  • Social Media
    1
    • Shares, Likes & Comments
      1
      • Facebook
        1

Article Description

2-Pentylpiperidine, named conmaculatin, a novel volatile alkaloid related to coniine was identified from the renowned toxic weed Conium maculatum L. (Apiaceae). The structure of conmaculatin was corroborated by synthesis (8 steps starting from cyclohexanol, overall yield 12%). Conmaculatin’s strong peripheral and central antinociceptive activity in mice was observed in a narrow dose range (10–20 mg/kg). It was found to be lethal in doses higher than 20 mg/kg.

Bibliographic Details

Radulović, Niko; Dorđević, Nevenka; Denić, Marija; Pinheiro, Mariana Martins Gomes; Fernandes, Patricia Dias; Boylan, Fabio

Elsevier BV

Agricultural and Biological Sciences; Pharmacology, Toxicology and Pharmaceutics

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