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Cell proliferation and apoptosis: dual-signal hypothesis tested in tuberculous pleuritis using mycobacterial antigens

FEMS Immunology and Medical Microbiology, ISSN: 0928-8244, Vol: 41, Issue: 1, Page: 85-92
2004
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Article Description

Antigens and mitogens have the innate ability to trigger cell proliferation and apoptosis thus exhibiting a dual-signal phenomenon. This dual-signal hypothesis was tested with mycobacterial antigens (PPD and heat killed Mycobacterium tuberculosis – MTB) in tuberculous pleuritis patients where the immune response is protective and compartmentalized. We compared and correlated the cell-cycle analysis and antigen-induced apoptosis in normal and patients’ peripheral blood mononuclear cells (PBMCs) and patients’ pleural fluid mononuclear cells (PFMCs).

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