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Apocarotenoids from the fresh roots of Rehmannia glutinosa and their anti-pulmonary fibrosis activity

Fitoterapia, ISSN: 0367-326X, Vol: 179, Page: 106247
2024
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Article Description

Six undescribed compounds ( 1 – 6 ) and twenty-three known analogues ( 7 – 29 ) were isolated from the fresh roots of Rehmannia glutinosa. The structures of the compounds ( 1 – 29 ) were established through the application of spectroscopic analysis. Compounds 3, 4, 6, 8, 13, 18, 21, 22, 25, and 28 exhibited excellent anti-pulmonary fibrosis activity. The potential mechanistic pathway of 3 was also investigated, whose results indicate that compound 3 ameliorate TGF-β1 induced BEAS-2B cell injury via PI3K/AKT/NF-κB signaling pathway.

Bibliographic Details

Li, Xiang-Da; Cao, Yan-Gang; Zhang, Yu-Han; Ren, Ying-Jie; Zeng, Meng-Nan; Liu, Yan-Ling; Chen, Xu; Ma, Xin-Yi; Zhao, Bing-Xian; Zheng, Xiao-Ke; Feng, Wei-Sheng

Elsevier BV

Pharmacology, Toxicology and Pharmaceutics

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