Integrated microbiomic and metabolomic analyses reveal the mechanisms by which bee pollen and royal jelly lipid extracts ameliorate colitis in mice
Food Research International, ISSN: 0963-9969, Vol: 171, Page: 113069
2023
- 4Citations
- 11Captures
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Metrics Details
- Citations4
- Citation Indexes4
- CrossRef4
- Captures11
- Readers11
- 11
Article Description
Bee pollen (BP) and royal jelly (RJ) have shown therapeutic effects against colitis, but the functional components contained therein remain elusive. Here, we used an integrated microbiomic-metabolomic strategy to clarify the mechanism by which bee pollen lipid extracts (BPL) and royal jelly lipid extracts (RJL) ameliorated dextran sulfate sodium (DSS)-induced colitis in mice. Lipidomic results showed that levels of ceramide (Cer), lysophosphatidylcholine (LPC), phosphatidylcholine (PC), and phosphatidylethanolamine (PE) were significantly higher in BPL than in RJL. The anti-inflammatory efficacy of BPL surpassed that of RJL, although both BPL and RJL could attenuate DSS-induced colitis through several mechanisms: reducing the disease activity index (DAI); decreasing histopathological damage; inhibiting the expression of genes encoding proinflammatory cytokines; improving intestinal microbial community structure, and modulating host metabolism. These findings demonstrated that BPL and RJL have great potential as functional ingredients for the production of dietary supplements to prevent early colitis.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0963996923006142; http://dx.doi.org/10.1016/j.foodres.2023.113069; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85161313812&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/37330827; https://linkinghub.elsevier.com/retrieve/pii/S0963996923006142; https://dx.doi.org/10.1016/j.foodres.2023.113069
Elsevier BV
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