The use of thiols by ribonucleotide reductase
Free Radical Biology and Medicine, ISSN: 0891-5849, Vol: 49, Issue: 11, Page: 1617-1628
2010
- 93Citations
- 72Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations93
- Citation Indexes92
- CrossRef92
- 92
- Patent Family Citations1
- Patent Families1
- Captures72
- Readers72
- 72
Review Description
Ribonucleotide reductase (RNR) catalyzes the rate-limiting de novo synthesis of 2′-deoxyribonucleotides from the corresponding ribonucleotides and thereby provides balanced deoxyribonucleotide pools required for error-free DNA replication and repair. The essential role of RNR in DNA synthesis and the use of DNA as genetic material has made it an important target for the development of anticancer and antiviral agents. The most well known feature of the universal RNR reaction in all kingdoms of life is the involvement of protein free radicals. Redox-active cysteines, thiyl radicals, and thiol redox proteins of the thioredoxin superfamily play major roles in the catalytic mechanism. The involvement of cysteine residues in catalysis is common to all three classes of RNR. Taking account of the recent progress in this field of research, this review focuses on the use of thiols in the redox mechanism of RNR enzymes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S089158491000537X; http://dx.doi.org/10.1016/j.freeradbiomed.2010.09.005; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78049374613&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/20851762; https://linkinghub.elsevier.com/retrieve/pii/S089158491000537X; https://dx.doi.org/10.1016/j.freeradbiomed.2010.09.005
Elsevier BV
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