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Coenzyme Q 10 deficiency disrupts lipid metabolism by altering cholesterol homeostasis in neurons

Free Radical Biology and Medicine, ISSN: 0891-5849, Vol: 229, Page: 441-457
2025
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Article Description

Coenzyme Q 10 (CoQ 10 ) is a critical component of the mitochondrial respiratory chain. CoQ 10 deficiencies cause a variety of clinical syndromes, often involving encephalopathies. The heterogeneity of clinical manifestations implies different pathomechanisms, reflecting CoQ 10 involvement in several biological processes. One such process is cholesterol homeostasis, since CoQ 10 is synthesized through the mevalonate pathway, which also produces cholesterol. To elucidate the role of lipid dysfunction in the pathogenesis of CoQ 10 deficiency, we investigated lipid metabolism in human CoQ 10 deficient iPSCs-derived neurons, and in SH-SY5Y neurons after pharmacological manipulation of the mevalonate pathway. We show that CoQ 10 deficiency causes alterations in cholesterol homeostasis, fatty acids oxidation, phospholipids and sphingolipids synthesis in neurons. These alterations depend on the molecular defect, and on the residual CoQ 10 levels. Our results imply that CoQ 10 deficiencies can induce pathology by altering lipid homeostasis and the composition of cellular membranes. These findings provide further understanding of the mechanisms underlying CoQ 10 deficiency and point to potential novel therapeutic targets.

Bibliographic Details

Pesini, Alba; Barriocanal-Casado, Eliana; Compagnoni, Giacomo Monzio; Hidalgo-Gutierrez, Agustin; Yanez, Giussepe; Bakkali, Mohammed; Chhonker, Yashpal S; Kleiner, Giulio; Larrea, Delfina; Tadesse, Saba; Lopez, Luis Carlos; Murry, Daryl J; Di Fonzo, Alessio; Area-Gomez, Estela; Quinzii, Catarina M

Elsevier BV

Biochemistry, Genetics and Molecular Biology; Medicine

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