Phosphoinositide 3-kinase family in channel catfish and their regulated expression after bacterial infection
Fish & Shellfish Immunology, ISSN: 1050-4648, Vol: 49, Page: 364-373
2016
- 11Citations
- 17Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations11
- Citation Indexes11
- CrossRef11
- 11
- Captures17
- Readers17
- 17
Article Description
The phosphoinositide-3-kinase (PI3Ks) family of lipid kinases is widely conserved from yeast to mammals. In this work, we identified a total of 14 members of the PI3Ks from the channel catfish genome and transcriptome and conducted phylogenetic and syntenic analyses of these genes. The expression profiles after infection with Edwardsiella ictaluri and Flavobacterium columnare were examined to determine the involvement of PI3Ks in immune responses after bacterial infection in catfish. The results indicated that PI3Ks genes including all of the catalytic subunit and several regulatory subunits genes were widely regulated after bacterial infection. The expression patterns were quite different when challenged with different bacteria. The PI3Ks were up-regulated rapidly at the early stage after ESC infection, but their induced expression was much slower, at the middle stage after columnaris infection. RNA-Seq datasets indicated that PI3K genes may be expressed at different levels in different catfish differing in their resistance levels against columnaris. Future studies are required to confirm and validate these observations. Taken together, this study indicated that PI3K genes may be involved as a part of the defense responses of catfish after infections, and they could be one of the determinants for disease resistance.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S105046481630002X; http://dx.doi.org/10.1016/j.fsi.2016.01.002; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84955283993&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/26772478; https://linkinghub.elsevier.com/retrieve/pii/S105046481630002X; https://dx.doi.org/10.1016/j.fsi.2016.01.002
Elsevier BV
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