Galectin 1 overexpression in breast cancer tissues: Relation to serum matrix metalloproteinase 2 and 9 activity
Gene Reports, ISSN: 2452-0144, Vol: 7, Page: 184-188
2017
- 3Citations
- 8Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Elevated expression of galectins correlates with neoplastic progression in certain malignancies. Matrix Metalloproteinases (MMPs) have been implicated in metastatic and angiogenic processes. Gal-1 promoted tumor invasion in oral cancer cell lines in part by augmenting MMP-2 and MMP-9 expression and enzymatic activities. Our aim was to assess the expression of Galectin-1 mRNA and correlate its expression with the clinico-pathological parameters and with potent serum (MMP 2, 9) activity in breast cancer. Semi quantitative RT PCR analysis was done on all breast tissue samples (malignant and benign). Gelatin zymography was performed in order to detect both latent and activated forms of serum MMP-2 and 9 in the same patients. There was a significant relation between Galectin-1 expression and the histological grade, stage of the tumor, presence of lymph node metastasis and potent MMP-2 and MMP-9 activity. Galectin-1 could be a promising potential marker for breast cancer.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2452014417300213; http://dx.doi.org/10.1016/j.genrep.2017.04.002; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85019143243&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S2452014417300213; https://dx.doi.org/10.1016/j.genrep.2017.04.002
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know