CD59: Biological function and its potential for drug target action
Gene Reports, ISSN: 2452-0144, Vol: 31, Page: 101772
2023
- 2Citations
- 10Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Review Description
CD59 is a major inhibitor of membrane attack complex (MAC) formation, which is anchored to the cell membrane by glycosylphosphatidylinositol (GPI). The protein is widely expressed in most human tissues. Several studies have reported the involvement of CD59 with several diseases such as paroxysmal nocturnal hemoglobinuria (PNH), cancer, peripheral demyelination, multiple sclerosis, diabetes mellitus, and viral infections. Herein, we summarized the biological structure and expression pattern of CD59, and its biological function, and focused on discussing the involvement of CD59 in several diseases and its potential for therapeutic use.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2452014423000341; http://dx.doi.org/10.1016/j.genrep.2023.101772; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85151494854&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S2452014423000341; https://dx.doi.org/10.1016/j.genrep.2023.101772
Elsevier BV
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