Analysis of the conserved neurotrophic factor MANF in the Drosophila adult brain
Gene Expression Patterns, ISSN: 1567-133X, Vol: 18, Issue: 1, Page: 8-15
2015
- 17Citations
- 23Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations17
- Citation Indexes17
- 17
- CrossRef16
- Captures23
- Readers23
- 23
Article Description
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an evolutionarily conserved neurotrophic factor that supports and protects dopaminergic neurons. The Drosophila MANF (DmMANF) null mutant animals die during early development, and DmMANF is required for the maintenance of dopamine positive neurites. The aim of this study was to investigate the role of DmMANF during later developmental stages. Here we report that DmMANF expression in the adult brain is much wider than in the embryonic and larval stages. It is expressed in both glia and neurons including dopaminergic neurons. Clonal analysis showed that DmMANF is not required cell-autonomously for the differentiation of either glia or dopaminergic neurons. In addition, DmMANF overexpression resulted in no apparent abnormal dopaminergic phenotype while DmMANF silencing in glia resulted in prolonged larval stage.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1567133X15000320; http://dx.doi.org/10.1016/j.gep.2015.04.002; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84928898955&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/25917377; https://linkinghub.elsevier.com/retrieve/pii/S1567133X15000320; https://dx.doi.org/10.1016/j.gep.2015.04.002
Elsevier BV
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