Tumor trofoblástico del lecho placentario: reporte de un caso
Clínica e Investigación en Ginecología y Obstetricia, ISSN: 0210-573X, Vol: 48, Issue: 4, Page: 100671
2021
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Case Description
El tumor trofoblástico del lecho placentario es una afección muy infrecuente que forma parte del grupo de las neoplasias trofoblásticas gestacionales. Se origina generalmente tras un aborto o gestación normal a partir de la proliferación patológica del trofoblasto intermedio extravelloso, que puede ocurrir en meses o años tras la gestación. Su presentación clínica habitual es el sangrado uterino anómalo, la amenorrea y unos niveles de β-hCG bajos, en contra de lo que ocurre con el coriocarcinoma o la mola invasiva. El tratamiento de elección es la histerectomía junto con linfadenectomía pélvica. Es particularmente resistente a la quimioterapia, y un 30% de las pacientes presentan metástasis al diagnóstico. Se presenta un caso clínico de un tumor trofoblástico del lecho placentario diagnosticado en nuestro centro en julio de 2018, en una paciente con infertilidad que tras 3 abortos espontáneos comenzó con unos niveles de β-hCG bajos, pero en meseta y con tendencia al alza. Se aborda el enfoque diagnóstico y terapéutico que recibió, así como la evolución hasta la actualidad. Placental site trophoblastic tumour (PSTT) is a very rare pathology that is part of the group of gestational trophoblastic neoplasia (GTN). It generally develops after a nonmolar abortion or term pregnancy from the pathological proliferation of extravillous intermediate trophoblast that can occur months or years after gestation. Its usual clinical presentation is abnormal uterine bleeding, amenorrhoea, and low levels of β-hCG, in contrast to choriocarcinoma or invasive mole. The treatment of choice is hysterectomy along with pelvic lymphadenectomy. It is particularly resistant to chemotherapy and 30% of patients present metastatic disease on diagnosis. A clinical case of PSTT diagnosed at our centre in July 2018 in a patient with infertility who, after 3 spontaneous abortions, debuted with low levels of β-hCG but on a plateau and with an upward trend. The diagnostic and therapeutic approach she received is addressed, as well as the evolution to date.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0210573X21000307; http://dx.doi.org/10.1016/j.gine.2021.100671; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85107682499&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S0210573X21000307; https://dx.doi.org/10.1016/j.gine.2021.100671
Elsevier BV
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