HMGA2 overexpression activates IGF2BP2 to stabilize APLP2 via m6A modification and promote pancreatic cancer progression
Heliyon, ISSN: 2405-8440, Vol: 10, Issue: 5, Page: e27268
2024
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Most Recent News
New Pancreatic Cancer Study Results from Huazhong University of Science and Technology Described (HMGA2 overexpression activates IGF2BP2 to stabilize APLP2 via m6A modification and promote pancreatic cancer progression)
2024 MAR 18 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Daily -- New study results on pancreatic cancer have been published. According
Article Description
Pancreatic cancer is a highly aggressive malignancy of the digestive system, with occult onset, rapid progression, and poor prognosis. The genetic heterogeneity of pancreatic cancer contributes to its highly malignant biological behavior. HMGA2 is overexpressed in tumors and is known to regulate tumor progression in various cancers through the HMGA2-IGF2BP2 axis, but its role and mechanism in pancreatic cancer remain unclear. In this study, we demonstrated that HMGA2 promotes pancreatic cancer progression. We further revealed that HMGA2 upregulates IGF2BP2, which stabilizes APLP2 mRNA via m6A modification, thereby promoting pancreatic cancer progression. These results indicate that HMGA2/IGF2BP2/APLP2 signaling axis regulates the progression of pancreatic cancer.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2405844024032997; http://dx.doi.org/10.1016/j.heliyon.2024.e27268; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85186342735&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/38449630; https://linkinghub.elsevier.com/retrieve/pii/S2405844024032997; https://dx.doi.org/10.1016/j.heliyon.2024.e27268
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