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The Epidemiology of Endometrial and Ovarian Cancer

Hematology/Oncology Clinics of North America, ISSN: 0889-8588, Vol: 26, Issue: 1, Page: 1-12
2012
  • 169
    Citations
  • 0
    Usage
  • 269
    Captures
  • 1
    Mentions
  • 36
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    169
  • Captures
    269
  • Mentions
    1
    • References
      1
      • Wikipedia
        1
  • Social Media
    36
    • Shares, Likes & Comments
      36
      • Facebook
        36

Review Description

Late menarche, giving birth, breastfeeding, oral contraceptive use, IUD use, and tubal ligation decrease risk for both endometrial and ovarian cancer, while more ovulatory cycles, obesity, use of talc in genital hygiene, and late menopause increase risk. Despite these similarities, different explanations are proposed: estrogen excess for endometrial and incessant ovulation for ovarian cancer. Common pathways could include reproductive tissue turnover with accumulation of PTEN or p53 mutations or an immunebased explanation involving mucin proteins. Seeking unified explanations for risk factors common to both cancers could lead to new perspectives on how to prevent these common and lethal gynecologic cancers. © 2012 Elsevier Inc.

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