Increased CD45RO + CD62L + CD4 + T-cell subpopulation responsible for Th2 response in Kimura’s disease
Human Immunology, ISSN: 0198-8859, Vol: 74, Issue: 9, Page: 1097-1102
2013
- 12Citations
- 6Captures
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Metrics Details
- Citations12
- Citation Indexes12
- 12
- CrossRef8
- Captures6
- Readers6
Article Description
Kimura’s disease is characterized by subcutaneous masses, eosinophilia, and markedly elevated serum immunoglobulin E, suggesting that T helper (Th)2 cells may play a role in the pathogenesis. We investigated Th2 cytokine synthesis by mononuclear cells and possible Th1/Th2 subpopulations in Kimura’s disease. Peripheral blood samples were obtained from seven patients with Kimura’s disease and CD4 + T-cell subpopulations separated by CD45RO and CD62L were isolated. Purified cells were stimulated with PHA or anti-CD3 mAb, and the cytokine levels were measured by Cytometric Bead Array kit. Peripheral blood mononuclear cells in the majority of the patients produced Th2 cytokines such as interleukin (IL)-3, IL-4, IL-5, IL-13 or GM-CSF higher than those of controls. The ratio of CD45RO + CD62L + cells in CD4 + T cells was increased in six out of seven patients compared to age-matched controls. Especially, patient 1 had remarkably increased levels of CD45RO + CD62L + population in CD4 + T cells. In addition, IL-4 production levels by CD45RO + CD62L + CD4 + T cells of patients 1 and 2 were higher than those of their CD45RO + CD62L − CD4 + T cells, in the same manner as those by a normal control. Taken together, the synthesis of Th2 cytokines and CD62L-positive subpopulation in CD45RO + CD4 + T cells, which may represent characteristics of Th2, are increased in patients with Kimura’s disease, suggesting that deviation to Th2 may involve in pathogenesis of the disease.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0198885913001444; http://dx.doi.org/10.1016/j.humimm.2013.06.001; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84880963993&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/23747992; https://linkinghub.elsevier.com/retrieve/pii/S0198885913001444; https://dx.doi.org/10.1016/j.humimm.2013.06.001
Elsevier BV
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