Glutathione-mediated activation of a disulfide containing Fe 3+ complex
Inorganica Chimica Acta, ISSN: 0020-1693, Vol: 490, Page: 139-143
2019
- 2Citations
- 7Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Metal complexes containing ligands that can be cleaved using biological reductants are possible alternatives to traditional photocaged metal ions. This strategy has been demonstrated in this proof-of-concept study with a disulfide containing Fe 3+ complex, FeL1Cl. The loss of tight Fe 3+ complexation due to disulfide reduction is observed through a decrease in a ligand to metal charge transfer band in its UV–vis spectrum. The mechanism of this reaction was investigated using mass spectrometry and stopped flow kinetics. A coumarin fluorescence assay was used to determine the ability of this complex to catalyze Fenton chemistry and produce hydroxyl radical. Hydroxyl radical production by FeL1Cl was low but in the presence of the reductant glutathione, hydroxyl radical production is increased, suggesting that reduction of the disulfide bond by glutathione uncages the reactivity of the Fe center in this complex.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S002016931930115X; http://dx.doi.org/10.1016/j.ica.2019.03.006; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85062638867&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S002016931930115X; https://dx.doi.org/10.1016/j.ica.2019.03.006
Elsevier BV
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