A novel controlled drug delivery system based on alginate hydrogel/chitosan micelle composites
International Journal of Biological Macromolecules, ISSN: 0141-8130, Vol: 107, Issue: PartA, Page: 855-864
2018
- 98Citations
- 152Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations98
- Citation Indexes98
- 98
- CrossRef58
- Captures152
- Readers152
- 152
Article Description
In this study, we present a novel cross-linked unimolecular micelle based on chitosan. For controlling drug delivery via oral administration, emodin (EMO) encapsulated micelles were loaded into sodium alginate hydrogel matrix to construct the pH-sensitive hydrogel/micelle composites. The optimized formulation of micelle that consists of 8.06% CaCl 2, 1.71% chitosan and 26.52% β-GP was obtained by the combination of Box-Behnken experimental design and response surface methodology. The morphological analysis showed that the micelles exhibited a smaller diameter of about 80 nm in aqueous solution, but dilated to 100–200 nm in hydrogel owing to the formation of polyelectrolyte complexes. The physical characteristics in simulated digestive fluids were investigated, demonstrating that the ratio of hydrogel to micelle distinctly affected swelling, degradation and in vitro drug release behaviors. The hydrogel/micelle (1:1) exhibited a sustained-release profile, while hydrogel/micelle (3:1) exhibited a colon-specific profile. Their corresponding release mechanisms revealed that the release of drug from these two formulations followed a complex process, in which several mechanisms were involved or occurred simultaneously. These results demonstrated that the pH-sensitive hydrogel/micelle composites constructed with biocompatible materials can be a promising sustained-release or site-specific drug delivery system for instable or hydrophobic drugs.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0141813017320421; http://dx.doi.org/10.1016/j.ijbiomac.2017.09.065; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85029766224&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/28935541; https://linkinghub.elsevier.com/retrieve/pii/S0141813017320421; https://dx.doi.org/10.1016/j.ijbiomac.2017.09.065
Elsevier BV
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