Chronic high dose captopril decreases total heart rate variability and increases heart rate in C57BL/6J mice
International Journal of Cardiology, ISSN: 0167-5273, Vol: 136, Issue: 2, Page: 211-213
2009
- 6Citations
- 10Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations6
- Citation Indexes6
- CrossRef6
- Captures10
- Readers10
- 10
Article Description
The effects of high dose captopril, within the therapeutic range, on autonomic activity are unknown in those with normal cardiovascular function. Thus the study aims were to assess the effects of high dose captopril on autonomic function in mice. Autonomic activity was measured using heart rate variability (HRV). ECG recordings were obtained from 18 Male C57BL/6J mice (20–25 g) subdivided into control ( N = 8) or mice receiving oral captopril (0.688 mg/ml captopril in the drinking water for 6 weeks, N = 10). HRV results for linear and non-linear parameters were attenuated following chronic captopril for 6 weeks compared to control. Captopril was associated with a trend for an increase in average heart rate and approximate entropy (ApEn), a non-linear measure of HRV decreased significantly compared to control ( p < 0.05). In conclusion high dose captopril reduces total HRV and increases heart rate in normotensive mice with normal cardiac function.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S016752730800555X; http://dx.doi.org/10.1016/j.ijcard.2008.03.082; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=67650718374&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/18606470; https://linkinghub.elsevier.com/retrieve/pii/S016752730800555X; https://dx.doi.org/10.1016/j.ijcard.2008.03.082
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know