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Platelet function analysis: A comparison of methods

International Journal of Cardiology, ISSN: 0167-5273, Vol: 145, Issue: 1, Page: 167-168
2010
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Article Description

Variability in response to clopidogrel has been well described, with residual platelet reactivity (RPR) after treatment in 5–44% of patients. New point-of-care (POC) devices have been developed in an attempt to identify poor responders at risk of adverse outcomes, with a view to eventually guide titration of anti-platelets. We sought to assess sensitivity/specificity of the Accumetrics VerifyNow device for measuring responsiveness to clopidogrel in patients undergoing elective PCI compared to the more specific tool: flow-cytometric analysis using VAsodilator-Stimulated Phosphoprotein (VASP). Our findings suggest that larger replication studies and standardised guidelines are required before POC devices may be routinely used in clinical practice.

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