Impact of gold nanoparticles (AuNPs) on eosinophils isolated from male and female individuals
Immunobiology, ISSN: 0171-2985, Vol: 228, Issue: 6, Page: 152762
2023
- 1Citations
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Article Description
It is well established that some differences exist between the male and female immune systems. Despites this, a sex-based analysis is not frequently performed in most scientific published reports. Knowing that inflammation is a common undesired effect observed resulting from nanoparticle (NP) exposure, we investigate here how in vitro treatment of gold NPs with a primary size of 20 and 70 nm (AuNP 20 and AuNP 70, respectively) will alter the biology of human eosinophils isolated from men and women blood. We found that treatment of AuNP 70, but not AuNP 20, significantly delay apoptosis only in eosinophils isolated from women. AuNPs were found to decrease eosinophil phagocytosis, however, significance was only observed in AuNP 20 -induced eosinophils isolated from women. The production of IL-8 was significantly increased in response to both AuNPs but only in eosinophils isolated from men and the production of IL-1β was increased in AuNPs-induced eosinophils, although significance was observed only in AuNP 70 -induced eosinophils isolated from women. We conclude that future studies investigating the toxicity of AuNPs (or other NPs) should include a sex-based analysis, especially if the tested NPs have potential medical applications knowing the increased interest in the development of personalized precision medicine.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0171298523045643; http://dx.doi.org/10.1016/j.imbio.2023.152762; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85178044499&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/38006680; https://linkinghub.elsevier.com/retrieve/pii/S0171298523045643; https://dx.doi.org/10.1016/j.imbio.2023.152762
Elsevier BV
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