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Illuminating the Fc dependence of SARS-CoV-2 neutralization

Immunity, ISSN: 1074-7613, Vol: 54, Issue: 9, Page: 1912-1914
2021
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Article Description

Monoclonal antibodies show efficacy in treating COVID-19, but the functional requirements for protection are unclear. In this issue of Immunity, Ullah et al. (2021) develop a stable SARS-CoV-2 reporter virus and use bioluminescence imaging to longitudinally monitor infection and assess neutralizing monoclonal antibody interventions in mice. They find that antibody-mediated protection depends on the Fc domain and Fc-gamma receptor-expressing immune cells.

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