Plant-derived anti-inflammatory compounds affect MIF tautomerase activity
International Immunopharmacology, ISSN: 1567-5769, Vol: 5, Issue: 5, Page: 849-856
2005
- 46Citations
- 55Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations46
- Citation Indexes46
- 46
- CrossRef30
- Captures55
- Readers55
- 55
Article Description
The cytokine macrophage migration inhibitory factor (MIF) has recently emerged as a crucial factor in the pathogenesis of rheumatoid arthritis (RA). It is debated whether the MIF mediated tautomeric conversion of either phenylpyruvate or of its other phenolic substrates is implicated in the pro-inflammatory action of this cytokine. Traditional herbal remedies have been used for centuries to alleviate inflammatory ailments of many kinds including arthritis. Several of their active ingredients identified are mono- or poly-phenol derivatives. In the present study the effect of some anti-inflammatory plant phenols on MIF mediated tautomerism of phenylpyruvate was investigated. Curcumin and caffeic acid were found to be the most potent inhibitors, exhibiting IC 50 values in the submicromolar range in the ketonase assay. Resveratrol and umbelliferon were almost as potent inhibitors as the antipyretic–analgetic drug acetaminophen. Our results reveal MIF as a possible target for the herbal anti-rheumatic agents.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1567576905000056; http://dx.doi.org/10.1016/j.intimp.2004.12.017; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=15044363485&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/15778121; https://linkinghub.elsevier.com/retrieve/pii/S1567576905000056; https://dx.doi.org/10.1016/j.intimp.2004.12.017
Elsevier BV
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