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Involvement of prostaglandin receptors (EPR2–4) in in vivo immunosuppression of PGE2 in rat skin transplant model

International Immunopharmacology, ISSN: 1567-5769, Vol: 5, Issue: 7, Page: 1131-1139
2005
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Article Description

Prostaglandin E2 (PGE2) is known to modulate immune responses and is widely viewed as a general immunosuppressant. There have been recognized four receptors for PGE2 (EP1–EP4 receptor) so far, and EP2 and EP4 receptors are mainly involved in the immunosuppressive effect of PGE2 in vitro. In the present study we examined the in vivo immunosuppressive effects of selective EP receptor agonists using a high-responder rat skin transplantation model.

Bibliographic Details

Fujimoto, Yoshimi; Iwagaki, Hiromi; Ozaki, Michitaka; Ogino, Tetsuya; Murata, Hiroshi; Sun, Dong Sheng; Sadamori, Hiroshi; Takahashi, Hideo Kohka; Tanaka, Noriaki; Yagi, Takahito

Elsevier BV

Medicine; Immunology and Microbiology; Pharmacology, Toxicology and Pharmaceutics

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