All- trans -retinoic acid accelerates the differentiation of human B lymphocytes maturing into plasma cells
International Immunopharmacology, ISSN: 1567-5769, Vol: 5, Issue: 13, Page: 1830-1838
2005
- 43Citations
- 22Captures
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Metrics Details
- Citations43
- Citation Indexes43
- 43
- CrossRef36
- Captures22
- Readers22
- 22
Article Description
There is a growing body of evidences suggesting the important role of vitamin A for the optimal maintenance and functioning of immune system. It is now well established that retinoic acid (RA), a product of oxidative metabolism of vitamin A, is the most active vitamin A derivative physiologically. In this study, we examined the role of RA in B cell maturation in T cell-dependent activation pathway. RA enhanced the immunoglobulin synthesis by tonsillar B cells in anti-CD40 plus IL-10-mediated culture system. When the kinetics of B cells with different phenotypic characteristics were monitored during 9 days culture period by flow cytometric analysis, it displayed the increase of the B cells with plasma cell phenotype (CD38+/CD20−/IgD−) in the presence of RA. As resting B cells from tonsil expressed mRNA of the RA receptors α, β, γ and RXRα by reverse transcriptase-polymerase chain reaction, it is certain that RA effect is mediated by RA receptors. Taken together, this study showed that retinoic acid could accelerate the differentiation of B cells maturing into antibody producing cells.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1567576905001517; http://dx.doi.org/10.1016/j.intimp.2005.06.002; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=27744550926&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/16275619; https://linkinghub.elsevier.com/retrieve/pii/S1567576905001517; https://dx.doi.org/10.1016/j.intimp.2005.06.002
Elsevier BV
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