Utilizing Polymer Micelle to Control Dye J-aggregation and Enhance Its Theranostic Capability
iScience, ISSN: 2589-0042, Vol: 22, Page: 229-239
2019
- 33Citations
- 30Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations33
- Citation Indexes33
- 33
- CrossRef29
- Captures30
- Readers30
- 30
Article Description
We utilize polymer micelle to precisely control indocyanine green (ICG) J-aggregation in a fast and highly efficient way. In addition to simple encapsulation, the polymer micelle plays a role as a host template to drive ICG J-aggregation by the synergy of electrostatic and hydrophobic attractions. We further demonstrate that, due to the robust host-guest interaction, the intact of ICG J-aggregate will be secured by the polymer encapsulation during the intracellular and in vivo incubation. These features make this hierarchical assembly between ICG J-aggregate and the micelle polymer a promising biomedicine for cancer phototheranostics. Therefore the complex micelles are further modified by introduction of doxorubicin for chemotherapy and DNA aptamer for tumor targeting, and the final multi-functional micellar medicine shows high therapeutic efficacy for tumor, i.e., the tumor can be completely eliminated with no local reoccurrence and without long-term toxicity or side effects during a 24-day period after the treatment.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2589004219304729; http://dx.doi.org/10.1016/j.isci.2019.11.022; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85075548102&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/31786519; https://linkinghub.elsevier.com/retrieve/pii/S2589004219304729; https://dx.doi.org/10.1016/j.isci.2019.11.022
Elsevier BV
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