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RORγt-driven T H 17 Cell Differentiation Requires Epigenetic Control by the Swi/Snf Chromatin Remodeling Complex

iScience, ISSN: 2589-0042, Vol: 23, Issue: 5, Page: 101106
2020
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Article Description

Epigenetic regulation, including chromatin accessibility and posttranslational modifications of histones, is of importance for T cell lineage decision. T H 17 cells play a critical role in protective mucosal immunity and pathogenic multiple autoimmune diseases. The differentiation of T H 17 cells is dictated by a master transcription factor, RORγt. However, the epigenetic mechanism that controls T H 17 cell differentiation remains poorly understood. Here we show that the Swi/Snf complex is required for T H 17-mediated cytokine production both in vitro and in vivo. We demonstrate that RORγt recruits and forms a complex with the Swi/Snf complex to cooperate for the RORγt-mediated epigenetic modifications of target genes, including both permissive and repressive ones for T H 17 cell differentiation. Our findings thus highlight the Swi/Snf complex as an essential epigenetic regulator of T H 17 cell differentiation and provide a basis for the understanding of how a master transcription factor RORγt collaborates with the Swi/Snf complex to govern epigenetic regulation.

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