RORγt-driven T H 17 Cell Differentiation Requires Epigenetic Control by the Swi/Snf Chromatin Remodeling Complex
iScience, ISSN: 2589-0042, Vol: 23, Issue: 5, Page: 101106
2020
- 17Citations
- 12Captures
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Metrics Details
- Citations17
- Citation Indexes17
- 17
- CrossRef13
- Captures12
- Readers12
- 12
Article Description
Epigenetic regulation, including chromatin accessibility and posttranslational modifications of histones, is of importance for T cell lineage decision. T H 17 cells play a critical role in protective mucosal immunity and pathogenic multiple autoimmune diseases. The differentiation of T H 17 cells is dictated by a master transcription factor, RORγt. However, the epigenetic mechanism that controls T H 17 cell differentiation remains poorly understood. Here we show that the Swi/Snf complex is required for T H 17-mediated cytokine production both in vitro and in vivo. We demonstrate that RORγt recruits and forms a complex with the Swi/Snf complex to cooperate for the RORγt-mediated epigenetic modifications of target genes, including both permissive and repressive ones for T H 17 cell differentiation. Our findings thus highlight the Swi/Snf complex as an essential epigenetic regulator of T H 17 cell differentiation and provide a basis for the understanding of how a master transcription factor RORγt collaborates with the Swi/Snf complex to govern epigenetic regulation.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2589004220302911; http://dx.doi.org/10.1016/j.isci.2020.101106; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85084616298&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/32434140; https://linkinghub.elsevier.com/retrieve/pii/S2589004220302911; https://dx.doi.org/10.1016/j.isci.2020.101106
Elsevier BV
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