Identification of a neural development gene expression signature in colon cancer stem cells reveals a role for EGR2 in tumorigenesis
iScience, ISSN: 2589-0042, Vol: 25, Issue: 7, Page: 104498
2022
- 11Citations
- 19Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations11
- Citation Indexes11
- CrossRef11
- 10
- Captures19
- Readers19
- 19
Article Description
Recent evidence demonstrates that colon cancer stem cells (CSCs) can generate neurons that synapse with tumor innervating fibers required for tumorigenesis and disease progression. Greater understanding of the mechanisms that regulate CSC driven tumor neurogenesis may therefore lead to more effective treatments. RNA-sequencing analyses of ALDH Positive CSCs from colon cancer patient-derived organoids (PDOs) and xenografts (PDXs) showed CSCs to be enriched for neural development genes. Functional analyses of genes differentially expressed in CSCs from PDO and PDX models demonstrated the neural crest stem cell (NCSC) regulator EGR2 to be required for tumor growth and to control expression of homebox superfamily embryonic master transcriptional regulator HOX genes and the neural stem cell and master cell fate regulator SOX2. These data support CSCs as the source of tumor neurogenesis and suggest that targeting EGR2 may provide a therapeutic differentiation strategy to eliminate CSCs and block nervous system driven disease progression.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2589004222007696; http://dx.doi.org/10.1016/j.isci.2022.104498; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85131929080&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/35720265; https://linkinghub.elsevier.com/retrieve/pii/S2589004222007696; https://dx.doi.org/10.1016/j.isci.2022.104498
Elsevier BV
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