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Identification of a neural development gene expression signature in colon cancer stem cells reveals a role for EGR2 in tumorigenesis

iScience, ISSN: 2589-0042, Vol: 25, Issue: 7, Page: 104498
2022
  • 11
    Citations
  • 0
    Usage
  • 19
    Captures
  • 0
    Mentions
  • 33
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    11
  • Captures
    19
  • Social Media
    33
    • Shares, Likes & Comments
      33
      • Facebook
        33

Article Description

Recent evidence demonstrates that colon cancer stem cells (CSCs) can generate neurons that synapse with tumor innervating fibers required for tumorigenesis and disease progression. Greater understanding of the mechanisms that regulate CSC driven tumor neurogenesis may therefore lead to more effective treatments. RNA-sequencing analyses of ALDH Positive CSCs from colon cancer patient-derived organoids (PDOs) and xenografts (PDXs) showed CSCs to be enriched for neural development genes. Functional analyses of genes differentially expressed in CSCs from PDO and PDX models demonstrated the neural crest stem cell (NCSC) regulator EGR2 to be required for tumor growth and to control expression of homebox superfamily embryonic master transcriptional regulator HOX genes and the neural stem cell and master cell fate regulator SOX2. These data support CSCs as the source of tumor neurogenesis and suggest that targeting EGR2 may provide a therapeutic differentiation strategy to eliminate CSCs and block nervous system driven disease progression.

Bibliographic Details

Regan, Joseph L; Schumacher, Dirk; Staudte, Stephanie; Steffen, Andreas; Lesche, Ralf; Toedling, Joern; Jourdan, Thibaud; Haybaeck, Johannes; Golob-Schwarzl, Nicole; Mumberg, Dominik; Henderson, David; Győrffy, Balázs; Regenbrecht, Christian R A; Keilholz, Ulrich; Schäfer, Reinhold; Lange, Martin

Elsevier BV

Multidisciplinary

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