An association study of HLA with levofloxacin-induced severe cutaneous adverse drug reactions in Han Chinese
iScience, ISSN: 2589-0042, Vol: 26, Issue: 8, Page: 107391
2023
- 1Citations
- 5Captures
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Metrics Details
- Citations1
- Citation Indexes1
- Captures5
- Readers5
Article Description
Levofloxacin-induced severe cutaneous adverse drug reactions (LEV-SCARs) remain unexplored. An association study of human leukocyte antigen ( HLA ) alleles with LEV-SCARs among 12 patients, 806 healthy subjects, and 100 levofloxacin-tolerant individuals was performed. The carrier frequencies of HLA-B∗13:01 (odds ratio [OR]: 4.50; 95% confidence interval [CI]: 1.15–17.65; p = 0.043), HLA-B∗13:02 (OR: 6.14; 95% CI: 1.73–21.76; p = 0.0072), and serotype B13 (OR: 17.73; 95% CI: 3.61–86.95; p = 4.85 × 10 −5 ) in patients with LEV-SCARs were significantly higher than those of levofloxacin-tolerant individuals. Molecular docking analysis suggested that levofloxacin formed more stable binding models with HLA-B∗13:01 and HLA-B∗13:02 than with non-risk HLA-B∗46:01. Mass spectrometry revealed that nonapeptides bound to HLA-B∗13:02 shifted at several positions after exposure to levofloxacin. Prospective screening for serotype B13 (sensitivity: 83%, specificity: 78%) and alternative drug treatment for carriers may significantly decrease the incidence of LEV-SCARs.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2589004223014682; http://dx.doi.org/10.1016/j.isci.2023.107391; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85166285687&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/37554438; https://linkinghub.elsevier.com/retrieve/pii/S2589004223014682; https://dx.doi.org/10.1016/j.isci.2023.107391
Elsevier BV
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