MIF modulates p38/ERK phosphorylation via MKP-1 induction in sarcoidosis
iScience, ISSN: 2589-0042, Vol: 27, Issue: 1, Page: 108746
2024
- 1Citations
- 4Captures
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Article Description
Macrophage migration inhibitory factor (MIF) is a versatile cytokine that influences a variety of cellular processes important for immune regulation and tissue homeostasis. Sarcoidosis is a granulomatous disease characterized by extensive local inflammation and increased T helper cell mediated cytokines. We have shown that MIF has a modulatory role in cytokine networks in sarcoidosis. We investigated the effect of exogenous MIF on sarcoidosis alveolar macrophages (AMs), CD14 + monocytes and peripheral blood mononuclear cells (PBMCs). Our results showed that MIF negatively regulates the increased MAPKs (pp38 and pERK1/2) activation by inducing Mitogen-activated protein kinase phosphatase (MKP)-1. We found that MIF decreased IL-6 and IL-1β production, increased the percentage of regulatory T-cells (Tregs), and induced IL-1R antagonist (IL-1RA) and IL-10 production. Thus, the results of our study suggest that exogenous MIF modulates MAPK activation by inducing MKP-1and Tregs as well as IL-10 and IL-1RA, and hence plays a modulatory role in immune activation in sarcoidosis.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2589004223028237; http://dx.doi.org/10.1016/j.isci.2023.108746; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85182220522&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/38299032; https://linkinghub.elsevier.com/retrieve/pii/S2589004223028237; https://dx.doi.org/10.1016/j.isci.2023.108746
Elsevier BV
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