RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
iScience, ISSN: 2589-0042, Vol: 27, Issue: 4, Page: 109524
2024
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Most Recent News
Investigators from Barshop Institute of Longevity & Aging Studies Zero in on Life Sciences (Rad51 Separation of Function Mutation Maintenance but Preserves Dsb Repair)
2024 JUN 06 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Life Science Daily -- Data detailed on Life Sciences have been presented.
Article Description
Homologous recombination (HR) protects replication forks (RFs) and repairs DNA double-strand breaks (DSBs). Within HR, BRCA2 regulates RAD51 via two interaction regions: the BRC repeats to form filaments on single-stranded DNA and exon 27 (Ex27) to stabilize the filament. Here, we identified a RAD51 S181P mutant that selectively disrupted the RAD51-Ex27 association while maintaining interaction with BRC repeat and proficiently forming filaments capable of DNA binding and strand invasion. Interestingly, RAD51 S181P was defective for RF protection/restart but proficient for DSB repair. Our data suggest that Ex27-mediated stabilization of RAD51 filaments is required for the protection of RFs, while it seems dispensable for the repair of DSBs.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2589004224007454; http://dx.doi.org/10.1016/j.isci.2024.109524; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85189497725&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/38577109; https://linkinghub.elsevier.com/retrieve/pii/S2589004224007454; https://dx.doi.org/10.1016/j.isci.2024.109524
Elsevier BV
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