The role of Testis-Specific Protein Y-encoded-Like 2 in kidney injury
iScience, ISSN: 2589-0042, Vol: 27, Issue: 5, Page: 109594
2024
- 2Citations
- 1Captures
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Article Description
Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). Recent findings suggest that Testis-Specific Protein Y-encoded-Like 2 (TSPYL2) plays a fibrogenic role in diabetes-associated renal injury. However, the role of TSPYL2 in IRI-induced kidney damage is not entirely clear. In this study, we found that the expression of TSPYL2 was upregulated in a mouse model of AKI and in the hypoxia/reoxygenation (H/R) cell model. Knockdown of TSPYL2 attenuated kidney injury after IRI. More specifically, the knockdown of TSPYL2 or aminocarboxymuconate-semialdehyde decarboxylase (ACMSD) alleviated renal IRI-induced mitochondrial dysfunction and oxidative stress in vitro and in vivo. Further investigation showed that TSPYL2 regulated SREBP-2 acetylation by inhibiting SIRT1 and promoting p300 activity, thereby promoting the transcriptional activity of ACMSD. In conclusion, TSPYL2 was identified as a pivotal regulator of IRI-induced kidney damage by activating ACMSD, which may lead to NAD+ content and the damaging response in the kidney.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2589004224008162; http://dx.doi.org/10.1016/j.isci.2024.109594; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85190452009&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/38665207; https://linkinghub.elsevier.com/retrieve/pii/S2589004224008162; https://dx.doi.org/10.1016/j.isci.2024.109594
Elsevier BV
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